Presented without comment, warranty, or context - other than these might help a wandering code hacker. When using SigV4, you must specify a ‘host’ parameter boto.s3.connection.HostRequiredError: BotoClientError: When using SigV4, you must specify a 'host' parameter. To fix, switch conn_s3 = boto.connect_s3() for conn_s3 = boto.connect_s3(host='s3.amazonaws.com') You can see a list of endpoints here. boto.exception.S3ResponseError: S3ResponseError: 400 Bad Request Make sure you’re specifying the correct hostname (see above) for the bucket’s region.